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Click here or scroll down to respond to this candidate Curriculum Vitae
Name : Dr. Prabhat Kumar
Date of Birth : July Street Address , 1967
Father&#Street Address ;s Name : Prof. Dr. V.N.P. Srivastava
Nationality : Indian
Permanent Address : Street Address , Ground Floor, Sector - 1
Vaishali, Ghaziabad - 201010
(Uttar Pradesh)
Mobile No. :
PHONE NUMBER AVAILABLE
PHONE NUMBER AVAILABLE
E. mail : EMAIL AVAILABLE
Summary :
. I have a total experience of more than 17 years in research and
development of new chemical entities, active pharmaceutical
ingredients, intermediates and have a expertise in medicinal
chemistry, synthetic organic chemistry, process development,
technology transfer, scale ups, chemical synthesis, custom synthesis
/ contract research, new product developments.
. I have given expert guidance to designing, synthesis and development
of more than 2000 heterocyclic new compounds/products by following
various synthetic routes, name reactions & techniques.
. I have given expert guidance to the process development, technology
transfer, scale up of ~25 molecules.
. Expert in STN search analysis for novelty of compounds, non
infringement analysis, literature search by reaxys/Scifinder.
. Patent manuscripts preparation and drafting claims (IPR). Know about
the patent laws of India, USA & Europe. IND & ANDA and DMF filing
. Manage & execute the projects of chemical synthesis, drug discovery &
process development (Project management).
. Established & manage the functioning of R & D labs and 20 Scientists
(PhDs, MSc & M Pharms) are reporting to me.
. Have a experience of contract research of international pharma
companies such as Novartis & Astra Zeneca.
. I have a 4 years of post doctoral research experience from abroad
(Konstanz University, Germany, one year & Chiba Institute of
Technology, Japan, two years) & Indian University (JNU, New Delhi). I
have synthesized derivatives of nucleosides, nucleotides, pteridines
& oligonucleotides during my post doctorate research work.
. Participated in five training programmes on Organizational Behaviour,
Communication Skills, Conflicts Management, Goals Settings , Team
Building, Leadership Skills, Corporate creativity organized by Torrent
Research Centre.
. I have published 9 Patents WOPHONE NUMBER AVAILABLE, CA2562130, USPHONE NUMBER AVAILABLE,
EP1748987, WOPHONE NUMBER AVAILABLE, EP2178835, CA2695031, WOPHONE NUMBER AVAILABLE, PPA
in Oct, 2011.
. A paper in Neuropharmacology 60 PHONE NUMBER AVAILABLE
Industrial or Research & Development skills:
. Expert in synthetic organic chemistry techniques, chemical reactions,
synthesis of novel compounds, scale up and process development in
kilograms.
. Expert in impurity identification, characterization and its synthesis,
process Development & technology transfer.
. Expert in data interpretation of UV/Visible, IR, and NMR (COSY, NOESY,
HMQC, Carbon -13, DEPT etc) Spectroscopy, LCMS, HPLC, GC, X-ray
crystallography, X-ray diffraction, thermogravimetric analysis,
Differential scanning calorimetry.
. Expert in ICH guidelines, cGMP & cGLP, SHE (safety health environment
policy), SOPs for documentation, instruments & equipments. Know about
MSDS (Material Safety Data Sheet) of hundreds of chemicals.
. Expert in providing data / support for CMC, IND, ANDA and DMF
documents preparation.
. Expert in working knowledge of Microwave synthesizer, parallel
synthesizer, NMR, HPLC, elemental analyzer etc.
. Expert in evaluating structure activity relationship (SAR) data,
toxicity data.
. Expert in interpretation of in vivo pharmacokinetics (ADME) data of
drugs/novel compounds and in-vitro screening, permeability &
metabolism data.
. Know about the Computer aided drug designing parameters or molecular
modeling
Experiences :
1) Presently, teaching chemistry on temporary basis to B.Pharm & MSc at
reputed University, colleges. Also, consulting services to chemical
companies.
2) Scientist 1, (Assistant General Manager, M-2) at Torrent Research
Centre, Torrent
Pharmaceuticals Ltd, Ahmedabad. Worked from March 2003 to Dec 2011 (~
9 years). The following are the achievements & job profile:
. Designed, Synthesized of about 450 novel compounds. Scale up and
process development of 5 novel compounds (5 Kgs). Published patent:
Novel Fused Pyridazine Derivatives (WOPHONE NUMBER AVAILABLE for anaemia, acute
& chronic kidney injury. IND filed in Jun, 2012.
. Designed, Synthesized of about 500 novel compounds. Scale up and
process development of 6 novel compounds (4 Kgs). Published patent :
Novel Substituted Piperidones as HSP Inducers (WOPHONE NUMBER AVAILABLE for
stroke, seizures & acute kidney injury.
. Designed, Synthesized of about 650 novel compounds. Scale up and
process development of 10 compounds (4Kgs). Published patent : 2-
Propene-1-one as HSP-70 Inducers (WOPHONE NUMBER AVAILABLE for Cerebral & Cardio
vascular diseases such as cerebral ischaemia and myocardial
infarction.
. Designed and Synthesized of about 350 novel compounds Scale up and
process development of 3 compounds (2Kgs) as TGR 5 & FXR agoinst for
diabetes & obesity.
. Designed and Synthesized about 300 novel compounds as sodium and
calcium channel blockers for neuropathic pain.
. Designed and Synthesized of about 25 novel compounds as CB1 & CB2
agoinst for irritable bowel syndrome.
. Evaluation of the STN search results for novelty, designing &
synthesis of novel compounds.
. Preparation of patent manuscript (IPR) i.e., drafting of the claims,
compilation of novel compounds data, writing of definitions, reaction
schemes & procedures of examples etc.
. Structure elucidation of novel compounds by 1H NMR, 13C NMR, COSY,
HMQC, DEPT, NOESY, Mass spectroscopy, Infrared spectroscopy, HPLC.
. Scale up, technology transfer & process development, of lead
compounds. Impurity identification, characterization and its
synthesis. Process Development of Clinical Trial Batch. Providing data
/ support for CMC, IND, ANDA and DMF documents preparation
. Metabolite identification, its characterization and synthesis.
. Investigational New Drug Application (IND)- drug substance dossier
preparation.
. Annual Budget Planning for the Projects, laboratory chemicals,
solvents, reagents, equipments etc. Preparation of procurement
justification.
. Preparation and following the time lines of deliverables of projects
(project management)
. Managing & training the 20 Scientists.
. Involved in selection of new therapeutic area / understanding of unmet
medical needs of diseases for new drug discovery.
. Attended the Symposium organized by Indian Society of Chemists and
Biologists in 2004(Rajkot) & 2008 (Delhi).
. Attended the Symposium on Current Trends in Drug Discovery Research
organized by Central Drugs Research Institute, Lucknow in 2007.
. Attended the MedChem Congress, 2011 at IICT/NIPER , Hyderabad.
. Attented the five training programmes on Organisational Behaviour,
Communication Skills, Conflicts Management, Goals Settings, Team
Building, Leadership Skills, Corporate creativity organized by Torrent
Research Centre.
2) Research Associate / Scientist in New Drug Discovery, Orchid
Research Centre,
Orchid Chemicals and Pharmaceuticals Ltd, Chennai from 2001 to 2003.
. Linezolid preparation in kgs , Oxazolidinones (antibacterial), COX-2
inhibitiors (pain).
3) Scientist at Department of Chemistry, Konstanz University, Konstanz,
Germany and worked with Prof. Wolfgang Pfleiderer from May, 2000 to
April
2001 (one year).
4) Research Associate at Centre for Biotechnology, Jawahar Lal Nehru
University,
New Delhi 110067 from July 1999 to April 2000 (~ a year).
Selected for Senior Research Associate of CSIR, New Delhi.
5) Post Doctorate Research Fellow at Department of Industrial Chemistry,
Chiba
Institute of Technology, Chiba, Japan with Prof. Hiroshi Takaku, from
Nov.1997 to June 1999 (~ 2 years).
6) Research and Development officer at Ind Swift Laboratories,
Derabassi, Patiala, Punjab from July 1997 to Oct. 1997 .
7) Research Associate of CSIR at Jawahar Lal Nehru University, New Delhi
from
Oct.1996 to July, 1997.
8) Junior Research Fellow (2 years) and Senior Research Fellow (1 year) in
a
research project of Department of Biotechnology, New Delhi at
Department of
Chemistry, University of Allahabad, Allahabad, Uttar Pradesh. Research
Work is
for Ph.D (1991 to 1996).
Publications :
1. A novel reagent for O-6 protection of 2'-deoxyguanosine/guanosine.
Nucleic Acids Symp Ser 1995;(34):151-2
2. Fluorophores for DNA/RNA labelling
Nucleic Acids Symp Ser 1995;(34):177-8
3. 2-Vinyl pyridine: A novel reagent for O-6 protection of guanosine.
Indian Journal of Chemistry; Vol. 35 B, July 1996, 657-661 in 1996
4. A new strategy for the synthesis of phosphorothioates of 2'-
deoxyriboligonucleotides
Indian Journal of Chemistry, Vol. 36B, Nov 1997, 1000-1004
5. Properities of a mixed backbone oligonucleotides containing 3'-o-
methylribonucleosides.
Bioorganic & Medicinal Chemistry Letters 9 PHONE NUMBER AVAILABLE
6. Synthesis of novel pteridines and their nucleosides
Synthesis.
7. 2-Propene-1-one as HSP-70 Inducers
Patent (WOPHONE NUMBER AVAILABLE, CA2562130, USPHONE NUMBER AVAILABLE,
EP1748987)
8. Novel Substituted Piperidones as HSP Inducers
Patent (WOPHONE NUMBER AVAILABLE, EP2178835, CA2695031)
9. Novel Fused Pyridazine Derivatives
Patent (WOPHONE NUMBER AVAILABLE
10. Delayed intervention in experimental stroke with TRC051384 - A small
molecule
HSP70 inducer.
Neuropharmacology 60 PHONE NUMBER AVAILABLE
Educational Qualification :
. Ph.D from Allahabad University, awarded in 1996
. M.Sc from Agra University in 1991 with 73 percentage.
. B.Sc from Delhi University in 1989 with 64.4 percentage.
. Senior Secondary from CBSE in 1985 with 74 percentage.
. Secondary from CBSE in 1983 with 68.4 percentage.
References :
. Prof. Krishna Misra, Department of Chemistry, Allahabad University,
Allahabad (UP). Ph : PHONE NUMBER AVAILABLE61377 ext.35 (O); Mobile:
PHONE NUMBER AVAILABLE
Date :
Place: Delhi -NCR
Prabhat Kumar
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