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Principal Scientist - Oncology

Serna Bio is building the worlds first map of the druggable transcriptome, systematically opening up the universe of RNA biology to small molecule drug discovery. Using our Discovery Platform, we are tackling the classically intractable targets ranging from coding and non-coding RNA.

We are looking for a Senior or Principal Scientist to begin the growth of our new US Labs. This person will report into our Director of Translational Biology and play a wide-ranging role in our efforts to accelerate programs to clinic

The Impact Youll Make

In this role, you will be an integral part of our biology programs team, leading internal drug discovery programs and influencing the scale up of our capabilities.

If you enjoy building things from the ground up, this role is for you! You will lead critical experiments both in-house and in collaboration with CROs, to progress our drug discovery programs. Working with the Chemistry, R&D and Bioinformatics teams, you will shape the strategy and screening cascades for key programs; as they move further through the drug discovery process.

Help guide the development and execution of key phenotypic assays, both in the lab and working with CROs
Develop the screening cascades for key drug discovery programs, and be responsible for progressing ML-enabled hits through relevant disease models
Review the data, statistical design and presenting the data to senior management and external stakeholders
Collaborate on strategy for our drug discovery program progression.
Help us grow by balancing and juggling a range of priorities in a rapidly evolving environment.
Deliver on cross functional projects directly with the Director of Translational Biology and our senior management team

The Team Youll Join

You will be a key member of our new US Programs Biology lab, advancing our Oncology programs through early drug discovery.

Requirements

The Experience Youll Need

Technical Requirements

PhD in molecular biology or a related field, Post Doc / plus at least 4 years industry experience
Experience with design, execution, and analysis of in-vitro and in-vivo pharmacology experiments including in vivo PK/PD and efficacy studies.
Demonstrable experience managing external collaborations and CROs
Demonstrated experience with CDX, PDX, and organoid disease models
Demonstrated experience with vector design, cloning and fluorescence and luminescence assays
Experience leading and prioritizing among multiple projects and efficiently advancing projects to Proof of Concept and no-go decisions.
Extensive experience with molecular biology skills (qPCR, Western blot, mammalian cell culture, cloning)
Demonstrated experience with data analysis in prism or similar tools and an understanding of statistical methods and experimental design
Experience working in cross-functional and distributed teams.
Ability to work under pressure, manage different projects and deliver to defined timelines
Excellent oral and written communication skills e.g. can tailor the complexity of communications as and when required, whilst maintaining clarity of communication
Bonus Marks: Previous experience at early stage biotech and the associated demands
Bonus Marks: Experience with iPS cell culture

Interpersonal skills

Exceptionally detail oriented with a love for organization
Excellent communication skills - able to present findings in writing whilst working collaboratively within the organization
Comfortable with juggling activities and can (re)prioritize effectively
Interested in working in a dynamic, high-paced environment

The Values Youll Share

We are unapologetically unrealistic: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: our ambition grounded in relentless execution of well designed experiments.
We are data-driven: Data trumps opinions.
We are humble: We understand the limitations of our knowledge and seek to learn from others to minimize them.
We are curious: Learning from the diverse perspectives of our fellow teammates, and from failure, is an essential part of how we make progress. At Serna Bio, we celebrate failure, mistakes, and the ability to learn from them.
We are one company: We operate with a company first, team second mentality. Our success comes from working as one interdisciplinary organization.

Benefits

What We Offer

The opportunity to accelerate your career. You will have the opportunity to grow your career as we grow our labs.
The opportunity to make a difference. Your work will have a direct impact on the experiments we run, and will influence our programs destined for the clinic to affect patient outcomes.
A place to explore the range of your interests. We pride ourselves in an environment that cultivates curiosity, creativity and autonomy. At Serna the why of things is always the most important question.
An environment designed to broaden your perspectives. We care deeply about inclusive working practices and diverse teams. Diversity is integral to our success, and an inclusive environment allows the team to do their best work.

Serna Bio

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