Job Description:

This is a 100% on site position.
This individual contributor role will collaborate across groups to plan, execute and analyze preclinical mouse studies. A wide range of animal models including syngeneic, GEM, CDX, PDX and humanized tumor models are used. The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work in a multi-functional team environment. You will gain and provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from target identification/validation to IND enabling activities and ultimately to clinical Proof of Concept in patients. You will characterize and develop small and large molecule therapeutics in close collaboration with your colleagues within in vivo pharmacology and partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams.
Ideal candidates will have strong technical skills, a background in characterizing the tumor microenvironment and possess excellent communication skills with a strong commitment to scientific objectivity and excellence. We value both what you do and how you do it.

Responsibilities:
Conduct in vivo studies to evaluate targets, combination strategies, biomarkers and establish efficacy, PK/PD relationships.
Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates. Advanced in vivo cancer models include syngeneic, genetically engineered mouse (GEM) and humanized tumor models.
Compliance with IACUC and AALAC regulations.
Interpretation, documentation and presentation of experiments within a multidisciplinary team environment.